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ĭry eye may occur in certain environmental conditions or while performing certain visual tasks like computer use movie watching etc. A patient is at risk of developing dry eye and if the OPI is < 1.0.

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If TBUT is more than IBI, value will be more than 1.0, so dryness will not occur. If the inter blink interval and TBUT are same dividing both give a value of 1.0. The ocular Protection Index can be calculated by dividing tear break-up time by inter blink interval (IBI). It is based on the idea that, even when the TBUT is normal, if the blink interval is too slow it may cause breakage of tear film due to increased evaporation. Ocular protection index (OPI) is used to quantify the interaction between tear film break-up time and blink intervals of a person. Even if TBUT value is under the normal limit, if the ocular protection index is less than 1.0, dryness and discomfort can occur. A value of less than 10 seconds is usually suspicious and may indicate tear film instability. Generally, a TBUT value of 10–35 seconds is considered normal. The time interval between the last blink and the distortion of the ring pattern gives the measurement of NIBUT. The rings will appear distorted when the cornea becomes dry. In annon-invasive tear breakup time measurement procedure, a grid or concentric ring pattern is projected onto the cornea and the patient is asked to blink. Taking two or more measurements and calculating its average may give a greater accuracy of measurement of TBUT. If the patient blinks before 10 seconds have elapsed, the test must be restarted. TBUT is the time interval between the last blink and appearance of the first randomly-distributed dry spot.A black spot indicating the dry area will appear a few seconds after each blink.Due to the fluorescein, the tear film will appear green in color.The patient is asked to blink once and to keep their eyes open.The lamp is switched to a cobalt blue filter.

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  • The eye is examined under a slit lamp with a low magnification and a broad beam covering the whole cornea.
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    Alternatively, impregnated flourescein strip moistened with preservative (benzalkonium chloride) free saline solution can also be used. Fluorescein 2% is instilled into the lower fornix of patient's eye.Procedure Procedure using fluorescein dye Evaporative dryness can also be seen in conditions like lagophthalmos, proptosis, Parkinson's disease, computer vision syndrome, contact lens use, drugs ( antihistamines, beta blockers, antispasmodics, diuretics) and vitamin A deficiency, amongst others. Tear film break-up time is abnormal in several conditions like aqueous tear deficiency, keratoconjunctivitis sicca, mucin deficiency, and meibomian gland disorders. Tearscope is a commercially available instrument used to measure NIBUT. In non-invasive procedure, a grid or concentric ring pattern is projected onto the cornea and the patient is asked to blink.

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    Noninvasive instruments (Oculus Keratograph 5M, Germany K5) are used for automatic non-invasive tear breakup time (NIBUT) measurements. The conventional and most common TBUT measurement method is using slit lamp and sodium fluorescein. TBUT test was first described by Norn MS, and then revised by Lemp and Holly. Factors like decreased tear production, increased evaporation rate, tearfilm instability, tear hyperosmolarity, inflammations, ocular surface damages etc. The volume of tear in the eye depends on two factors, drainage through the lacrimal passages and evaporation. It is a standard diagnostic procedure in the dry eye clinics. TFBUT measurement is an easy and fast method used to assess the stability of tear film. Tear break-up time (TBUT) also known as tear film break-up time (TFBUT) is the time taken for the first dry spot to appear on the cornea after a complete blink.








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